用這招，揪出你這個小壞「蛋」！
蛋白質是人體的重要成分，如果蛋白質出現問題，沒有被辨識處理，就容易產生疾病。
在我們體內，自有一套揪出有缺陷蛋白質的方法。
中研院分子生物研究所顏雪琪副研究員的團隊發現：
有一種蛋白質「CRL2」可以從蛋白的尾端特徵，辨識出有缺陷的蛋白，然後將它標記、清除。
發現這個機制，是蛋白質降解調控研究的里程碑，不僅可應用於生物工程，更有助於發展醫療策略，對治蛋白質品管缺陷導致的疾病。
本研究成果於今（107）年5月發表於國際期刊《分子細胞》（Molecular Cell），同時獲選為該期刊當期之重點論文，並以專文介紹。
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Many human diseases such as aging, degenerative neurological diseases, and cancer are related to the defects in proteins. To remove defective proteins, cells prune themselves through a quality control mechanism that separates the wheat from the chaff.
A group led by Dr. Hsueh-Chi Sherry Yen, Associate Research Fellow at the Institute of Molecular Biology of Academia Sinica, has uncovered an important quality control degradation system in human cells—a protein complex known as CRL2 that specifically recognizes, marks, and destroys aberrant proteins bearing unusual terminal sequences. The discovery of this quality control mechanism has set a milestone in the study of protein degradation control, offering new ideas that spur further innovation in the field protein bioengineering while also paving the way for new medical treatments for illnesses associated with protein quality defects. Their findings were published in Molecular Cell in May 2018 and also selected as a featured article of this issue.
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中研院新聞稿：
(中文) https://www.sinica.edu.tw/ch/news/5872
(English) https://www.sinica.edu.tw/en/news/5872
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[自由時報] 辨識、清除缺陷蛋白質 阿茲海默症 治療新契機
http://news.ltn.com.tw/news/focus/paper/1208254
[中央廣播電台]中研院發現「警察」蛋白質 助辨識「壞人」
https://news.rti.org.tw/news/view/id/413474
[中央社] 致病缺陷蛋白質怎麼抓 中研院找到品管機制
http://www.cna.com.tw/news/ahel/201806110139-1.aspx
[聯合報] 致病缺陷蛋白質怎麼抓 中研院找到品管機制
https://udn.com/news/story/7266/3192264
[生醫觀點] 中研院新發現！具品管機制蛋白質有助延緩老化
https://goo.gl/8wuttf
[GTV] 中研院發現「警察」蛋白 助辨病兆
https://www.youtube.com/watch?reload=9&v=QcgsBHTFgf0
[華視] 辨識.清除缺陷蛋白質 阿茲海默症有救了?
https://news.cts.com.tw/…/gener…/201806/201806121928081.html
#中研院分子生物研究所 #顏雪琪 中央研究院 分子生物研究所 Institute of Molecular Biology
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